The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

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The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

Trimethylamine-N-oxide (TMAO) is a small organic molecule, derived from the intestinal and hepatic metabolism of dietary choline and carnitine. Although the involvement of TMAO in the framework of many chronic diseases has been recently described, no evidence on its putative role in the central nervous system has been provided. The aim of this study was to evaluate whether TMAO is present at de...

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Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden.

BACKGROUND Trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, has mechanistic links to atherosclerotic coronary artery disease (CAD) pathogenesis and is associated with adverse outcomes. OBJECTIVES This study sought to examine the relationship between plasma TMAO levels and the complexity and burden of CAD and degree of subclinical myonecrosis. METH...

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Eggs as a dietary source for gut microbial production of trimethylamine-N-oxide.

Recent studies provide compelling evidence for a new nutritional pathway contributing to the development of atherosclerosis and incident risks of major adverse cardiovascular events such as heart attack, stroke, and death (reviewed in reference 1). The pathway was originally discovered on the basis of an unbiased metabolomics investigation searching for plasma analytes whose concentrations in s...

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Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects.

April 25, 2017 1671 CORRPONDENCE We previously showed gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin, and L-carnitine is linked to the development of cardiovascular diseases.1–3 We also recently reported that plasma TMAO levels are associated with incident thrombotic event risk in subjects, and that TMAO both enhances platelet responsiven...

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Microbial trimethylamine-N-oxide as a disease marker: something fishy?

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ژورنال

عنوان ژورنال: Nutrients

سال: 2017

ISSN: 2072-6643

DOI: 10.3390/nu9101053